Characters making faces
Derpy is not the only character known for making silly faces. Other characters also tend to contract this common symptom during strange occurrences, or sometimes intentionally.
Smug levels are imminently rising.
This is who I'm really am!
Fluffy Heart's Mind: Me sad
Everyone seems pretty normal...except Pinkie.
Pinkie's impersonation of the drama masks: Comedy...
"I don't get paid enough for this..."
Second place?! Of all the worst things that could happen...!
Derpy... I shall have my revenge!
Big and bold! Bigger and bolder! Biggest and boldest!
Of course, the writers know that once a face becomes a meme, there is no turning back!