Twist shares her name with a G1 So Soft pony. At some point prior to May 21, 2010, Twist's design was discussed when Lauren Faust was at Studio B Productions (now DHX Media Vancouver); Sabrina Alberghetti "was the one on the crew that was fighting for Twist's design to stay the way it was". Twist is slightly taller than normal foals, as she has skinnier legs and her nose is more bulbous than most other ponies. She shows several stereotypical nerdy traits, such as a curly red mane and tail, pale coat, large glasses, and a lisp. Her design is also used with a different mane and tail color for one of the nurses in Read It and Weep.
Twist makes her debut appearance in Call of the Cutie. She is picked on for being a "blank flank" by Diamond Tiara and Silver Spoon, until she discovers that her special talent is crafting confectionery, and she earns her cutie mark. She is a friend of Apple Bloom in this episode, but the two haven't been seen together since Apple Bloom joined the Cutie Mark Crusaders.
She appears in The Cutie Pox, joining in with Sweetie Belle and Scootaloo's attempts to guess what Apple Bloom's cutie mark was meant to be, thinking it was a delicious powdered donut. She remains next to the two Crusaders as they all watch in awe of Apple Bloom's loopty-hoop stunts.
Twist makes a background appearance in Family Appreciation Day, where she's the only pony (apart from Diamond Tiara) to be remotely paying attention in Filthy Rich's story.