There's a guy named henmo24 on YouTube.  He has 33 videos on YouTube.  This video he has out called "My MLP Season 4+ Wish List" and here are his top 10 predictions / wish list:

10.  A Different City (an episode taken place somewhere else in Equestria).

9.  Derpy Hooves episode.

8.  A Daring Do episode.

7.  Student becomes the Teacher (or a sub).

6.  Doctor Whooves episode.

5.  Sweetie Belle gets her Cutie Mark.

4.  Silver Spoon's redemption.

3.  Grudge Match (Gilda vs Rainbow Dash).

2.  The Equestria Games.

1.  A MLP movie (not counting Equestria Girls).