I'm referring to the season 2 episode Ponyville Confidential, when the Cutie Mark Crusaders go to work for the official Ponyville Schoolhouse newspaper, the Foal Free Press.

Scootaloo, Sweetie Belle, and Apple Bloom have their "Gabby Gums" gossip column (is it more like tabloid or yellow journalism?) in which they write about various gossip concerning Ponyville and even elsewhere in Equestria.

In one edition, the CMCs write about Mr. and Mrs. Cake allegedly planning to get divorced (although it is not actually true).

Now considering the series has had at least two marriages (Princess Cadance to Shining Armor and Cranky Doodle Donkey to Matilda), the reverse (divorce) perhaps could be tackled in MLP.

Why not?

Possible scenario: Scootaloo lives in Ponyville with her divorced mother. Scootaloo's older sister left Ponyville a while back with their biological father. That explains why Scootaloo looks up to Rainbow Dash as a sort of pseudo-sibling.